Where is transferrin receptor found?
Where is transferrin receptor found?
Transferrin receptors are expressed on the surfaces of all cells in concert with their need for iron. A truncated form of the extracellular domain of the receptor is produced by proteolytic cleavage and is present in the plasma in direct proportion to the total number of receptors expressed in all body tissues.
How does iron regulate transferrin receptor gene expression?
For most non-erythroid cells, iron can regulate the TfR expression in a reciprocal manner through modulating the stability of the receptor mRNA whereas in hemoglobin-synthesizing cells, the TfR expression is independent of the cellular iron loading.
What is human transferrin receptor?
The transferrin receptor is a membrane glycoprotein whose only clearly defined function is to mediate cellular uptake of iron from a plasma glycoprotein, transferrin.
How does transferrin enter the cell?
In the classical transferrin pathway, the transferrin iron complex enters the cell within an endosome. Acidification of the endosome releases the iron from transferrin so that it can enter the cell. The apotransferrin is delivered by the endosome to the plasma for reutilization.
Is transferrin made by the liver?
Transferrin (Trf), a serum-abundant metal-binding protein, is primarily synthesized in the liver. In the circulation, Trf binds to ferric iron (Fe3+) in a soluble, nontoxic form to deliver iron to the bone marrow and other tissues.
What causes low transferrin?
Low transferrin can be due to poor production of transferrin by the liver (where it’s made) or excessive loss of transferrin through the kidneys into the urine. Many conditions including infection and malignancy can depress transferrin levels. The transferrin is abnormally high in iron deficiency anemia.
What type of receptor is transferrin?
What is ferritin responsible for?
Ferritin, an iron storage protein, is the primary iron storage mechanism and is critical to iron homeostasis. Ferritin makes iron available for critical cellular processes while protecting lipids, DNA, and proteins from the potentially toxic effects of iron.
Which is more important iron or ferritin?
Ferritin is, therefore, a good indicator of how much iron is stored within your body with low levels indicating iron deficiency anaemia. Approximately one-quarter of the total iron in the body is stored as ferritin….Ferritin Level Chart.
| Amount (µg/L) | |
|---|---|
| Normal | 13-150 |
| Borderline high | 150-154 |
| High | >154 |