Should leucovorin be refrigerated?

Leucovorin Calcium Injection USP, 10 mg/mL, is supplied in sterile, single use vials as follows: NDC 55390-826-01 500 mg individually-boxed. Store in refrigerator 2° to 8°C (36° to 46°F). Protect from light.

How do you give leucovorin injection?

Leucovorin is administered at 200 mg/m2 by slow intravenous injection over a minimum of 3 minutes, followed by 5-fluorouracil at 370 mg/m2 by intravenous injection. 2. Leucovorin is administered at 20 mg/m2 by intravenous injection followed by 5-fluorouracil at 425 mg/m2 by intravenous injection.

Can leucovorin be pushed?

Should be administered IM, IV push, or IV infusion (15 minutes to 2 hours). Leucovorin should not be administered concurrently with methotrexate.

How do you take leucovorin calcium Injection?

Leucovorin Injection is given as a slow injection into veins under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised.

Is leucovorin the same as folic acid?

Leucovorin is also called folinic acid. It’s very similar, but not the same as folic acid. Folic acid is an over-the-counter dietary supplement for low folate levels, whereas leucovorin is only available by prescription, and it treats side effects from methotrexate and other anti-folate medications.

Does calcium gluconate need to be refrigerated?

Calcium Gluconate Injection will be stored in the surgery, pharmacy or ward of a hospital. The injection is kept in a cool dry place where the temperature stays below 30°C but not refrigerated.

Is leucovorin hazardous?

Irritating to eyes, respiratory system and skin. Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-existing organ (e.g. liver, kidney) damage is evident.

Why do you give leucovorin with 5-FU?

Leucovorin is common given with 5-FU to treat cancers of the colon, rectum, and other parts of the digestive system. It has been proven that adding leucovorin increases the effectiveness of 5-FU. Leucovorin can also be given with the chemotherapy drug tegaful-uracil, which is similar to 5-FU.

Why does leucovorin need to be given on time?

Doses of leucovorin rescue will be ordered at evenly spaced intervals, and it is critical to administer those on time. Severe immunosuppression and toxicity can occur if doses are missed or not given on time.

How do you take calcium injections?

When injected intravenously, calcium salts should be administered slowly through a small needle into a large vein to avoid too rapid an increase in serum calcium and extravasation of calcium solution into the surrounding tissue with resultant necrosis.

Is leucovorin calcium a chemotherapy?

Leucovorin is not a chemotherapy medication, but is given in conjunction with chemotherapy. Leucovorin can be used with the chemotherapy medication fluorouracil (5-FU). In this case, it is used to enhance the effects of the fluorouracil, in other words, to make the drug work better.