What functional groups are present in digoxin?
What functional groups are present in digoxin?
A cardenolide glycoside that is digitoxin β-hydroxylated at C-12….CHEBI:4551 – digoxin.
| digoxin is a Functional Parent of | |
|---|---|
| 12-O-acetyldigoxin Mass : 822.97510 Formula : C43H66O15 | 20,22-dihydrodigoxin Mass : 782.95430 Formula : C41H66O14 |
What is the structural difference between digoxin and Digitoxin?
Digoxin. Digoxin, 3β,14β-dihydroxy-5β-card-20(22)-enolide-3-rigitoxide (17.1. 2), is also a glycoside isolated from various types of foxgloves. It differs from digitoxin in that it has an additional hydroxyl group at C16 of the steroid skeleton.
What is the classification of digoxin?
Digoxin belongs to the class of medicines called digitalis glycosides. It is used to improve the strength and efficiency of the heart, or to control the rate and rhythm of the heartbeat. This leads to better blood circulation and reduced swelling of the hands and ankles in patients with heart problems.
What properties does digoxin have?
Digoxin is a positive inotropic and negative chronotropic drug 7, meaning that it increases the force of the heartbeat and decreases the heart rate. The decrease in heart rate is particularly useful in cases of atrial fibrillation, a condition characterized by a fast and irregular heartbeat.
What is digoxin made of?
Chemicals taken from foxglove are used to make a prescription drug called digoxin. Digitalis lanata is the major source of digoxin in the US. Foxglove is most commonly used for heart failure and fluid build up in the body (congestive heart failure or CHF) and irregular heartbeat (atrial fibrillation).
What is digoxin derived from?
Derived from the purple foxglove plant, Digoxin was first used to treat heart complaints 200 years ago.
What is the difference between digoxin and digitalis?
Digoxin, also called digitalis, helps an injured or weakened heart pump more efficiently. It strengthens the force of the heart muscle’s contractions, helps restore a normal, steady heart rhythm, and improves blood circulation. Digoxin is one of several medications used to treat the symptoms of heart failure.
What is the mechanism of digoxin?
Mechanism of Action Digoxin induces an increase in intracellular sodium that will drive an influx of calcium in the heart and cause an increase in contractility. Cardiac output increases with a subsequent decrease in ventricular filling pressures.
What is another name for digoxin?
Digoxin oral tablet is available as both a generic and brand-name drug. Brand name: Lanoxin. Digoxin is also available as an oral solution. Digoxin oral tablet is used to treat atrial fibrillation, mild to moderate heart failure in adults, and heart failure in children.
What is the action of digoxin?
Mechanism of action Digoxin binds to and inhibits the sodium/potassium-ATPase (sodium pump) within the plasma membrane of cardiac myocytes. This inhibition increases the intracellular sodium content which in turn increases the intracellular calcium content which leads to increased cardiac contractility.
How does digoxin work?
Digoxin helps by slowing down and controlling the heart rate. Digoxin comes in tablet, capsule, and liquid form. It works with minerals in the cells of the heart to reduce strain and keep the heart beating normally.
What is the mechanism of action of digoxin?